Elyssa Margolis
Associate Investigator, Gallo
Center
Adjunct Assistant Professor of Neurology, UCSF
Email: elyssam@gallo.ucsf.edu
Research
My research is focused on the heterogeneous
properties of ventral tegmental area (VTA) neurons,
which are the source of dopamine for many limbic brain
regions. I use anatomical, physiological, and
pharmacological techniques to resolve the properties
and organization of these midbrain neurons. In my lab,
we have found that while VTA neuron properties are very
heterogeneous, many properties, including sensitivity
to different opioids, sort by projection target. We
have also been investigating how mu and delta opioid
receptor signaling changes in addiction-related
conditions. We are using this physiological data to
inform the behavioral testing of possible novel targets
for more effective treatments for alcohol abuse.
Publications
Elyssa Margolis's publications
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