The Ernest Gallo Clinic and Research Center (Gallo Center) is one of the world's preeminent academic centers for the study of biological basis of alcohol and substance abuse. Gallo Center research has a remarkable track record of innovative and important discoveries of molecular, cellular and neuronal mechanisms that underlie alcoholism and substance abuse and their co-morbidities. Gallo Center discoveries of potential molecular targets for the development of therapeutic medications are extended through preclinical and proof-of-concept clinical studies. Gallo Center technologies are further developed through intellectual property licensing and joint development relationships with biotech and pharmaceutical companies.