(for complete list see lab home page for link to downloadable CV)

SELECTED ARTICLES

Khasar SG, Lin Y-H, Martin A, Dadgar J, McMahon T, Hundle B, Aley KO, Isenberg W, Green PG, Hodge, CH, Levine JD, Messing RO. A novel nociceptive signaling pathway demonstrated in PKCε-mutant mice. Neuron 24:253-260, 1999.

Hodge, CW, Mehmert K, Kelley SP, McMahon T, Haywood A, Olive MF, Wang D, Sanchez-Perez AM, Messing RO. Supersensitivity to allosteric GABAA modulators and alcohol in mice lacking PKCε. Nat. Neurosci. 2:997-1002, 1999.

McMahon T, Andersen R, Messing RO. PKCε mediates up-regulation of N-type calcium channels by ethanol. Mol. Pharmacol. 57:53-58, 2000.

Aley KO, Messing RO, Mochly-Rosen D, Levine JD. Chronic hypersensitivity for inflammatory nociceptor sensitization mediated by the ε isozyme of protein kinase. J. Neurosci. 20:4680-4685, 2000.

Walter H, McMahon T, Gerstin E, Dadgar J, Wang D, Messing RO. Ethanol regulates calcium channel subunits by protein kinase C δ-dependent and -independent mechanisms. J. Biol. Chem. 275: 25717-25722, 2000.

Dina OA, Barletta J, Chen XJ, Mutero A, Martin A, Messing RO and Levine JD. Key role for the ε isoform of protein kinase C in painful alcoholic neuropathy in the rat. J. Neurosci. 20:8614-8619, 2000.

Aley KO, Martin A, McMahon T, Levine JD, Messing RO. Nociceptor sensitization by extracellular signal-regulated kinases. J. Neurosci. 21:6933-6939, 2001.

Hodge CW, Raber J, Walter H, McMahon T, Sanchez-Perez AM, Olive MF, Mehmert K, Morrow AL, Messing RO. Decreased anxiety-like behavior, reduced stress hormones, and neurosteroid supersensitivity in mice lacking protein kinase C ε. J. Clin. Invest. 110:1003-1010, 2002.

Choi D-S, Wang D, Dadgar J, Chang WS, Messing RO. Conditional rescue of protein kinase C ε regulates ethanol preference and hypnotic sensitivity in adult mice. J. Neurosci. 22:9905-9911, 2002.

Chou W-H, Choi D-S, Zhang H, Mu D, McMahon T, Kharazia VN, Lowell CA, Ferriero DM, Messing RO. Neutrophil protein kinase C δ as a mediator of stroke-reperfusion injury. J. Clin. Invest. 114:49-56, 2004.

Choi D-S, Cascini M-G, Mailliard W, Young H, Paredes P, McMahon T, Diamond I, Bonci A, Messing RO. The equilibrative nucleoside transporter type 1 modulates ethanol intoxication and preference in mice. Nat. Neurosci. 7:855-861, 2004.

Newton PM, Orr CJ. Wallace MJ, Shin H-S, Messing RO. Deletion of N-type calcium channels blocks ethanol reward and reduces ethanol consumption in mice. J. Neurosci. 24:9862-9869, 2004.

Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH, Messing RO. The mGluR5 antagonist 6-methyl-s-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C ε-dependent mechanism. Mol. Pharmacol. 67:349-355, 2005.

Wallace MJ, Newton PM, Oyasu M, McMahon T, Chou W-H, Connolly J, Messing RO. Acute functional tolerance to ethanol mediated by protein kinase Cε. Neuropsychopharmacology, March 15 [Epub ahead of print], 2006.

Choi DS, Wang D, Yu G-Q, Zhu G, Kharazia VN, Paredes P, Chang WS, Deitchman JK, Mucke L, Messing RO. PKCε increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc. Nat. Acad. Sci. USA, 103:8215-8220, 2006.

Dina OA, Messing RO, Levine JD. Ethanol withdrawal induces hyperalgesia mediated by PKCε. Eur. J. Neurosci, Jun 26 [Epub ahead of print], 2006.

Newton PM, Kim JA, McGeehan AM, Paredes JP, Chu K, Wallace MJ, Roberts AJ, Hodge CW, Messing RO. Increased response to morphine in mice lacking protein kinase C ε. Genes Brain Behav. 2006 Aug 7; [Epub ahead of print]

Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hubner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. A semisynthetic epitope for kinase substrates. Nat Methods. 2007 May 7; [Epub ahead of print].

Lesscher HMB, McMahon T, Chou WH, Lasek AW, Connolly J, Kharazia VN, Messing RO. Amygdala PKC epsilon regulates corticotrophin releasing factor and anxiety-like behavior. Genes Brain Behav, 2007 Oct 1; [Epub ahead of print].

Qi Z-H, Song M, Wallace MJ, Wang D, Newton PM, McMahon T, Zhang C, Shokat KM, Messing RO. Protein kinase C epsilon phosphorylation of γ2 subunits regulates GABAA receptor sensitivity to ethanol and benzodiazepines. J. Biol. Chem. 2007 Oct 2; [Epub ahead of print]

Dina OA, Khasar SG, Alessandri-Haber N, Green PG, Messing RO, Levine JD. Alcohol-induced stress in painful peripheral neuropathy. Eur. J. Neurosci. 27:83-92, 2008. Epub 2007 Dec 17.

Durgan J, Cameron AJ, Saurin AT, Hanrahan S, Totty N, Messing RO, Parker PJ. The identification and characterization of novel PKC epsilon phosphorylation sites provides evidence for functional cross-talk within the PKC superfamily. Biochem, J. 2008 Jan 31; [Epub]; doi:10.1042/bj20071348.

REVIEWS

Olive MF and Messing RO. PKC isozymes and addiction. Mol. Neurobiol. 29:139-154, 2004.

Song M and Messing RO.Protein kinase C regulation of GABAAreceptors. Cell. Mol. Life Sci. 62:119-127, 2005.

Chou WH, Messing RO.Protein kinase C isozymes in stroke. Trends Cardiovasc. Med. 15:47-51, 2005.

Messing RO and Diamond I. Alcoholism. In: Encyclopedia of Life Sciences, Nature Publishing Group: London, www.els.net, 2005.

Newton PM, Messing RO. Intracellular signaling pathways that regulate behavioral responses to ethanol. Pharmacol Ther. 2006 Jan;109(1-2):227-37. Epub 2005 Aug 15.

BOOK CHAPTERS

Messing RO. Alcohol and the Nervous System. In: Neurology and General Medicine, Aminoff M., ed. 4th Edition. Churchill Livingstone-Elsevier, Philadelphia, PA, 2008, pp. 721-734.

Messing RO and Choi D-S. Animal Models to Study the Function of PKC Isozymes. In: Protein Kinase C Protocols. Methods in Molecular Biology series. Newton, ed. Humana Press, Totowa, NJ, 2003, pp. 455-473.