Home Investigators Dorit Ron, Ph.D. Publications
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Selected References for Dorit Ron:

Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Oct 1;415(1):77-85

Carnicella S, Kharazia V., Jeanblanc J., Janak PH and Ron D. GDNF – a fast acting potent inhibitor of motivation for alcohol seeking. PNAS. PNAS. 2008 Jun 10;105(23):8114-9.

GDNF reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of HSP90. Dao-Yao He and Dorit Ron. J. Biol. Chem. Accepted on March 14, 2008.

Dynorphin Is A Downstream Effector Of Striatal BDNF Regulation Of Ethanol. Marian L. Logrip, Patricia H. Janak, and Dorit Ron. FASEB J. 2008 Jul;22(7):2393-404.

Mind bomb-2 is an E3 ligase that ubiquitinates the nmda receptor NR2B subunit in a phosphorylation-dependent manner. Jurd R., Thornton C., Wang J., Luong K., Phamluong K., Kharazia V., Gibb S.L., and Ron D. J. Biol. Chem. 2008 Jan 4;283(1):301-10.

Newton PM, Ron D. Protein kinase C and alcohol addiction.  Pharmacol Res. 2007 Jun;55(6):570-7.

Wang J., Carnicella S., Phamluong K., Jeanblanc J., Ronesi J., Chaudhri N., Janak P.H., Lovinger D.M. and Ron D. Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior.  J. Neurosci. 2007;27 3593-3602.

Schilstrom B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D., Bonci A.Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors. J Neurosci. 2006 Aug 15;26(33):8549-58.

He, D.-Y. and Ron, D. Autoregulation of Glial Cell Line Derived Neurotrophic Factor Expression: Implications for the Long-Lasting Actions of the Anti-Addiction Drug, Ibogaine. FASEB J. 2006; 20(13):2420-2422.

Kiely, P.A., O'Gorman, D., Luong, K., Ron, D. and O'Connor, R. Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and {beta}1 Integrin To Promote Cell Migration. Mol. Cell. Biol. 2006;26 4041-4051.

Szumlinski K. K., Abernathy K. E., Oleson E. B., Klugmann M., Lominac K. D., He D-Y., Ron D., During M. and Kalivas P. W. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology. 2006 Apr;31(4):768-77.

Ashique, A.M., Kharazia, V., Yaka, R., Phamluong, K., Peterson, A.S., Ron, D. Localization of the scaffolding protein RACK1 in the developing and adult mouse brain. Brain Research, 1069: p. 31-38, 2006.

Janak P.H., Wolf F.,W, Heberlien U., Pandey S.C., Logrip M.L., and Ron D. BIG News In Alcohol Addiction: New Findings On Growth Factor Pathways BDNF, Insulin, And GDNF. Alcoholism: Clinical And Experimental Research, 30(2): p. 214-221, 2006.

Jeanblanc J., He D.-Y., McGough N.N.H, Logrip M.L., Phamluong K., Janak P.H., Ron D. The Dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. The Journal of Neuroscience, 26(5): p. 1457-1464, 2006.

Woodward, J. J., Ron, D., Winder, D., Roberto, M. From Blue States to Up States: A regional View of NMDA-Ethanol Interactions. Alcoholism: Clinical And Experimental Research, 30(2): p. 359-67, 2006.

Ron, D. and Janak, P.H. GDNF and Addiction. Reviews in the Neurosciences, 16(4): p. 277-285, 2005.

Ron, D. and Jurd, R. The "ups and downs" of signaling cascades in addiction. Science STKE, 2005. Science STKE 2005(309): p. re14, 2005.

Neesha Suvarna, Stephanie L. Borgland, Jun Wang, Khanhky Phamluong, Yves P. Auberson, Antonello Bonci, and Dorit Ron. Ethanol alters trafficking and functional NMDA receptor NR2 subunit ratio via H-RAS Journal of Biological Chemistry, 280(36): p. 31450-31459, 2005.

Dao-Yao He, Nancy N. H. McGough, Ajay Ravindranathan, Jerome Jeanblanc, Marian L. Logrip, Khanhky Phamluong, Patricia H. Janak, and Dorit Ron. Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption. Journal of Neuroscience, 25(3): p. 619-628, 2005. See also Nature Reviews Neuroscience, 6: p. 169, 2005.

McGough N. N. H., He D.-Y., Janak P. H., Phamluong, K., Janak P. H., Ron D. RACK1 and BDNF: A homeostatic pathway that regulates alcohol addiction. Journal of Neuroscience, 24(46): p. 10542-10552, 2004. See also This Week In the Journal.

Ron, D., Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol. (Review) Neuroscientist, 10(4): p. 325-336, 2004.

Thornton, C., Tang, K.-C., Phamluong, K., Luong, K., Vagts, A., Nikanjam, D., Yaka, R., and Ron, D. Spatial and temporal regulation of RACK1 function and NMDA receptor activity through WD40 motif-mediated dimerization. Journal of Biological Chemistry, 279(30): p. 31357-31364, 2004.

Yaka, R., Tang, K.-C., Camarini, R., Janak, P.H., and Ron, D. Fyn kinase and NR2B containing NMDA receptors regulate acute ethanol sensitivity but not intake or conditioned reward. Alcoholism: Clinical and Experimental Research, 27(11): p. 1736-1742, 2003.

Vagts, A.J., He, D.-Y., and Ron, D. Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcoholism: Clinical and Experimental Research, 27(10): p. 1599-1605, 2003.

Ungless, M., Singh, V., Crowder, T.L., Yaka, R., Ron, D., and Bonci, A. Corticotropin-releasing factor (CRF) requires CRF-binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron, 39: p. 401-407, 2003.

Thornton, C., Yaka, R., Dinh, S. and Ron, D. H-Ras Modulates N-Methyl-D-aspartate Receptor Function via Inhibition of Src Tyrosine Kinase Activity. Journal of Biological Chemistry, 278(26): p. 23823-23829, 2003.

Yaka, R., Phamluong, K. and Ron, D. Scaffolding of Fyn Kinase to the NMDA Receptor Determines Brain Region Sensitivity to Ethanol. Journal of Neuroscience, 23(9): p. 3623-3632, 2003.

Yaka, R., He, D.Y., Phamluong, K. and Ron, D. Pituitary adenylate cyclase activating polypeptide (PACAP 1-38) enhances NMDA receptor function and BDNF expression via rack. Journal of Biological Chemistry, 278(11): p. 9630-9638, 2003.

He, D.Y., Vagts, A.J., Yaka, R. and Ron, D. Ethanol Induces Gene Expression via Nuclear Compartmentalization of Receptor for Activated C Kinase 1. Molecular Pharmacology 62(2): p. 272-280, 2002.

Yaka, R., Thornton, C., Vagts, A.J., Phamluong, K., Bonci, A., and Ron, D. NMDA-receptor function is regulated by the inhibitory scaffolding protein RACK1. Proceedings of the National Academy of Sciences, 99: p. 5710-5715, 2002.

Ron, D., Vagts, A.J., Dohrman, D. P., Yaka, R., Jiang, Z., Yao, L., Crabbe, J., Grisel, J.E. and Diamond, I. Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB Journal, 14: p. 2303-2314, 2000.

Ron, D., Jiang, Z., Yao, L., Vagts, A.J., Diamond, I., Gordon, A.S. Coordinated movement of RACK1 with activated bIIPKC. Journal of Biological Chemistry, 274: p. 27039-27046, 1999.

Ron, D., Napolitano, E. W., Voronova, A., Vasquez, N.J., Roberts, D.N., Calio, B.L., Caothien, R.H., Pettiford, S.M., Wellik, S., Mandac, J.B., Kauvar, L. Direct interaction in T-cells between PKC and the Tyrosine Kinase p59fyn. Journal of Biological Chemistry, 274: p. 19003-19010, 1999.

Ron, D. and Kazanietz, M.G. New insights of Protein Kinase C and novel Phorbol Ester Receptors. FASEB Journal, 13: p.1658-1676,1999.

Rodriguez, M., Ron, D., Kazushige, T., Chen, C.-H., Mochly-Rosen, D. RACK1, a Protein Kinase C anchoring protein coordinates the binding of activated Protein Kinase C and select pleckstrin homologydomains in vitro. Biochemistry, 38: p. 13787-13794, 1999.

Yedovitzky, M., Mochly-Rosen, D., Ron, D., Gray, M. O., Johnson, J. A., Abramovitch, E., Cerasi, E., and Nesher, R. Translocation inhibitors define specificity of protein kinase C isozymes in pancreatic beta cells. Journal of Biological Chemistry (Communication), 272: p. 1417-1420, 1997.

Ron, D., Luo, J., and Mochly-Rosen, D. C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo. Journal of Biological Chemistry, 270: p. 24180-7, 1995.

Ron, D., and Mochly-Rosen, D. A new autoregulatory region in protein kinase C - the pseudo-RACK binding site. Proceedings of the National Academy of Sciences, 92: p. 492-496, 1995.

Ron, D., and Mochly-Rosen, D. Agonists and antagonists of protein kinase C function, derived from its binding proteins. Journal of Biological Chemistry (Communication), 269: p. 21395-21398, 1994.

Ron, D., Chen, C. H., Caldwell, J., Jamieson, L., Orr E., and Mochly-Rosen, D. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proceedings of the National Academy of Sciences, 91: p. 839-43, 1994.