Home Investigators Dorit Ron, Ph.D. Publications
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Selected References for Dorit Ron:

Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S. PKCbetaII modulates translation independently from mTOR and through RACK1. Biochem J. 2008 Jun 16. [Epub ahead of print]

Carnicella S, Kharazia V., Jeanblanc J., Janak PH and Ron D. GDNF – a fast acting potent inhibitor of motivation for alcohol seeking. PNAS. PNAS. 2008 Jun 10;105(23):8114-9.

GDNF reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of HSP90. Dao-Yao He and Dorit Ron. J. Biol. Chem. Accepted on March 14, 2008.

Dynorphin Is A Downstream Effector Of Striatal BDNF Regulation Of Ethanol. Marian L. Logrip, Patricia H. Janak, and Dorit Ron. FASEB J. published 2 April 2008.

Mind bomb-2 is an E3 ligase that ubiquitinates the nmda receptor NR2B subunit in a phosphorylation-dependent manner. Jurd R., Thornton C., Wang J., Luong K., Phamluong K., Kharazia V., Gibb S.L., and Ron D. J. Biol. Chem. published 25 October 2007.

Newton PM, Ron D. Protein kinase C and alcohol addiction.  Pharmacol Res. 2007 Jun;55(6):570-7.

Wang J., Carnicella S., Phamluong K., Jeanblanc J., Ronesi J., Chaudhri N., Janak P.H., Lovinger D.M. and Ron D. Ethanol Induces Long-Term Facilitation of NR2B-NMDA Receptor Activity in the Dorsal Striatum: Implications for Alcohol Drinking Behavior.  J. Neurosci. 2007;27 3593-3602.

Schilstrom B, Yaka R, Argilli E, Suvarna N, Schumann J, Chen BT, Carman M, Singh V, Mailliard WS, Ron D., Bonci A.Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors. J Neurosci. 2006 Aug 15;26(33):8549-58.

He, D.-Y. and Ron, D. Autoregulation of Glial Cell Line Derived Neurotrophic Factor Expression: Implications for the Long-Lasting Actions of the Anti-Addiction Drug, Ibogaine. FASEB J. 2006; 20(13):2420-2422.

Kiely, P.A., O'Gorman, D., Luong, K., Ron, D. and O'Connor, R. Insulin-Like Growth Factor I Controls a Mutually Exclusive Association of RACK1 with Protein Phosphatase 2A and {beta}1 Integrin To Promote Cell Migration. Mol. Cell. Biol. 2006;26 4041-4051.

Szumlinski K. K., Abernathy K. E., Oleson E. B., Klugmann M., Lominac K. D., He D-Y., Ron D., During M. and Kalivas P. W. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacology. 2006 Apr;31(4):768-77.

Ashique, A.M., Kharazia, V., Yaka, R., Phamluong, K., Peterson, A.S., Ron, D. Localization of the scaffolding protein RACK1 in the developing and adult mouse brain. Brain Research, 1069: p. 31-38, 2006.

Janak P.H., Wolf F.,W, Heberlien U., Pandey S.C., Logrip M.L., and Ron D. BIG News In Alcohol Addiction: New Findings On Growth Factor Pathways BDNF, Insulin, And GDNF. Alcoholism: Clinical And Experimental Research, 30(2): p. 214-221, 2006.

Jeanblanc J., He D.-Y., McGough N.N.H, Logrip M.L., Phamluong K., Janak P.H., Ron D. The Dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. The Journal of Neuroscience, 26(5): p. 1457-1464, 2006.

Woodward, J. J., Ron, D., Winder, D., Roberto, M. From Blue States to Up States: A regional View of NMDA-Ethanol Interactions. Alcoholism: Clinical And Experimental Research, 30(2): p. 359-67, 2006.

Ron, D. and Janak, P.H. GDNF and Addiction. Reviews in the Neurosciences, 16(4): p. 277-285, 2005.

Ron, D. and Jurd, R. The "ups and downs" of signaling cascades in addiction. Science STKE, 2005. Science STKE 2005(309): p. re14, 2005.

Neesha Suvarna, Stephanie L. Borgland, Jun Wang, Khanhky Phamluong, Yves P. Auberson, Antonello Bonci, and Dorit Ron. Ethanol alters trafficking and functional NMDA receptor NR2 subunit ratio via H-RAS Journal of Biological Chemistry, 280(36): p. 31450-31459, 2005.

Dao-Yao He, Nancy N. H. McGough, Ajay Ravindranathan, Jerome Jeanblanc, Marian L. Logrip, Khanhky Phamluong, Patricia H. Janak, and Dorit Ron. Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption. Journal of Neuroscience, 25(3): p. 619-628, 2005. See also Nature Reviews Neuroscience, 6: p. 169, 2005.

McGough N. N. H., He D.-Y., Janak P. H., Phamluong, K., Janak P. H., Ron D. RACK1 and BDNF: A homeostatic pathway that regulates alcohol addiction. Journal of Neuroscience, 24(46): p. 10542-10552, 2004. See also This Week In the Journal.

Ron, D., Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol. (Review) Neuroscientist, 10(4): p. 325-336, 2004.

Thornton, C., Tang, K.-C., Phamluong, K., Luong, K., Vagts, A., Nikanjam, D., Yaka, R., and Ron, D. Spatial and temporal regulation of RACK1 function and NMDA receptor activity through WD40 motif-mediated dimerization. Journal of Biological Chemistry, 279(30): p. 31357-31364, 2004.

Yaka, R., Tang, K.-C., Camarini, R., Janak, P.H., and Ron, D. Fyn kinase and NR2B containing NMDA receptors regulate acute ethanol sensitivity but not intake or conditioned reward. Alcoholism: Clinical and Experimental Research, 27(11): p. 1736-1742, 2003.

Vagts, A.J., He, D.-Y., and Ron, D. Cellular adaptation to chronic ethanol results in altered compartmentalization and function of the scaffolding protein RACK1. Alcoholism: Clinical and Experimental Research, 27(10): p. 1599-1605, 2003.

Ungless, M., Singh, V., Crowder, T.L., Yaka, R., Ron, D., and Bonci, A. Corticotropin-releasing factor (CRF) requires CRF-binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons. Neuron, 39: p. 401-407, 2003.

Thornton, C., Yaka, R., Dinh, S. and Ron, D. H-Ras Modulates N-Methyl-D-aspartate Receptor Function via Inhibition of Src Tyrosine Kinase Activity. Journal of Biological Chemistry, 278(26): p. 23823-23829, 2003.

Yaka, R., Phamluong, K. and Ron, D. Scaffolding of Fyn Kinase to the NMDA Receptor Determines Brain Region Sensitivity to Ethanol. Journal of Neuroscience, 23(9): p. 3623-3632, 2003.

Yaka, R., He, D.Y., Phamluong, K. and Ron, D. Pituitary adenylate cyclase activating polypeptide (PACAP 1-38) enhances NMDA receptor function and BDNF expression via rack. Journal of Biological Chemistry, 278(11): p. 9630-9638, 2003.

He, D.Y., Vagts, A.J., Yaka, R. and Ron, D. Ethanol Induces Gene Expression via Nuclear Compartmentalization of Receptor for Activated C Kinase 1. Molecular Pharmacology 62(2): p. 272-280, 2002.

Yaka, R., Thornton, C., Vagts, A.J., Phamluong, K., Bonci, A., and Ron, D. NMDA-receptor function is regulated by the inhibitory scaffolding protein RACK1. Proceedings of the National Academy of Sciences, 99: p. 5710-5715, 2002.

Ron, D., Vagts, A.J., Dohrman, D. P., Yaka, R., Jiang, Z., Yao, L., Crabbe, J., Grisel, J.E. and Diamond, I. Uncoupling of bIIPKC from its targeting protein RACK1 in response to ethanol in cultured cells and mouse brain. FASEB Journal, 14: p. 2303-2314, 2000.

Ron, D., Jiang, Z., Yao, L., Vagts, A.J., Diamond, I., Gordon, A.S. Coordinated movement of RACK1 with activated bIIPKC. Journal of Biological Chemistry, 274: p. 27039-27046, 1999.

Ron, D., Napolitano, E. W., Voronova, A., Vasquez, N.J., Roberts, D.N., Calio, B.L., Caothien, R.H., Pettiford, S.M., Wellik, S., Mandac, J.B., Kauvar, L. Direct interaction in T-cells between PKC and the Tyrosine Kinase p59fyn. Journal of Biological Chemistry, 274: p. 19003-19010, 1999.

Ron, D. and Kazanietz, M.G. New insights of Protein Kinase C and novel Phorbol Ester Receptors. FASEB Journal, 13: p.1658-1676,1999.

Rodriguez, M., Ron, D., Kazushige, T., Chen, C.-H., Mochly-Rosen, D. RACK1, a Protein Kinase C anchoring protein coordinates the binding of activated Protein Kinase C and select pleckstrin homologydomains in vitro. Biochemistry, 38: p. 13787-13794, 1999.

Yedovitzky, M., Mochly-Rosen, D., Ron, D., Gray, M. O., Johnson, J. A., Abramovitch, E., Cerasi, E., and Nesher, R. Translocation inhibitors define specificity of protein kinase C isozymes in pancreatic beta cells. Journal of Biological Chemistry (Communication), 272: p. 1417-1420, 1997.

Ron, D., Luo, J., and Mochly-Rosen, D. C2 region-derived peptides inhibit translocation and function of beta protein kinase C in vivo. Journal of Biological Chemistry, 270: p. 24180-7, 1995.

Ron, D., and Mochly-Rosen, D. A new autoregulatory region in protein kinase C - the pseudo-RACK binding site. Proceedings of the National Academy of Sciences, 92: p. 492-496, 1995.

Ron, D., and Mochly-Rosen, D. Agonists and antagonists of protein kinase C function, derived from its binding proteins. Journal of Biological Chemistry (Communication), 269: p. 21395-21398, 1994.

Ron, D., Chen, C. H., Caldwell, J., Jamieson, L., Orr E., and Mochly-Rosen, D. Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins. Proceedings of the National Academy of Sciences, 91: p. 839-43, 1994.