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Selected References for Jennifer Whistler

R.M. van Rijn, J.L. Whistler, M. Waldhoer. 2009. Opioid-receptor-heteromer-specific trafficking and pharmacology. Curr Opin Pharmacol.

L. He, J.A. Kim, J.L. Whistler. 2009. Biomarkers of morphine tolerance and dependence are prevented by morphine-induced endocytosis of a mutant {micro}-opioid receptor. FASEB J. 23(12):4327-34.

R.M. van Rijn, J.L. Whistler. 2009. The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biol Psychiatry. 66(8):777-84.

A. Ravindranathan, G. Joslyn, M. Robertson, M.A. Schuckit, J.L. Whistler, R.L. White. 2009. Functional characterization of human variants of the mu-opioid receptor gene. Proc Natl Acad Sci U S A. 106(26):10811-6.

L. He, J. Kim, C. Ou, W. McFadden, R.M. van Rijn, J.L. Whistler. 2009. Methadone antinociception is dependent on peripheral opioid receptors. J Pain. 10(4):369-79.


M.J. Wallace, P.M. Newton, T. McMahon, J. Connolly, A. Huibers, J. Whistler, R.O. Messing. 2009. PKCepsilon regulates behavioral sensitivity, binding and tolerance to the CB1 receptor agonist WIN55,212-2. Neuropsychopharmacology. 34(7):1733-42.

R.M. van Rijn, J.L. Whistler, 2008. The only way is up: preventing opiod tolerance by promoting cell surface expression of MOR-DOR heterodimers? Mol Interv. 8(6):277-80.

J.A. Kim, S. Bartlett, L. He, C.K. Nielsen, A.M. Chang, V. Kharazia, M. Waldhoer, C.J. Ou, S. Taylor, M. Ferwerda, D. Cado, J.L. Whistler. 2008. Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence. Current Biology. 18(2):129-135.  

L. Martini, J.L. Whistler. 2007. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr. Opin. Neurobiol. 17(5):556-64.

D. Thompson, M. Pusch, J.L. Whistler. 2007. Changes in G protein coupled receptor sorting protein affinity regulate post-endocytic targeting of G protein coupled receptors. J Biological Chemistry 282(40):29178-29185.

Y.F. Xia, L. He, J.L. Whistler, G.O. Hjelmstad. 2007. Acute Amphetamine Axposure Selectively Desensitizes kappa Opioid Receptors in the Nucleus Accumbens. Neuropsychopharmacology.

A.W. Lasek, P.H. Janak, L. He, J.L. Whistler, U Heberlein. 2007. Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. Genes Brain and Behavior. 6(8):728-735.

L. He, J.L. Whistler, 2007. The Biochemical Analysis of Methadone Modulation on Morphine-Induced Tolerance and Dependence in the Rat Brain. Pharmacology 79(4):193-202.

A. Tappe-Theodor, N. Agarwal, I. Katona, T. Rubino, L. Martini, J. Swiercz, K. Mackie, H. Monyer, D. Parolaro, J. Whistler, T. Kuner, R. Kuner. 2007. A Molecular Basis of Analgesic Tolerance to Cannabinoids. Journal of Neuroscience 27(15):4165-4177.

L. Martini, M. Waldhoer, M. Pusch, V. Kharazia, J. Fong, J.H. Lee, C. Freissmuth, J.L. Whistler. 2007. Ligand-induced down-regulation of cannabinoid 1 receptor is mediated by G-protein-coupled receptor-associated sorting protein GASP1. FASEB J 21(3):802-11.

J. Enquist,C. Skroder, J.L. Whistler, L.M. Leeh-Lundberg. 2006. Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor receptor endocytosis. Molecular Pharmacology 71(2):494-507.

S. Bartlett*, J. Enquist*, F.W. Hopf*, J. Lee, F. Gladher, V. Kharazia, W. Maillaird, M. Waldhoer, R Armstrong, A. Bonci and J.L. Whistler. 2005. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proceedings National Academy of Sciences 102(32):11520–11526.

L. He, and J.L. Whistler. 2005. An opiate cocktail that prevents morphine tolerance and dependence. Current Biology 15(11):1028-33.

M. Waldhoer, J. Fong, E. M. Lunzer, R. Jones, S. Sharma, E. Kostenis, P. Portoghese, J.L. Whistler. 2005. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proceedings National Academy of Sciences 102(25):9050-9055. Also featured on the cover.

S.E. Bartlett and J.L.Whistler 2005. The G protein coupled receptor handbook: Receptor Oligomerization and Trafficking. Humana Press, 309-322.

E. Kostenis, L. Martini, J. Ellis, M. Rosenkilde, M. Waldhoer, P. K. Norregaard, A. Heydorn, J.L. Whistler, G. Milligan. 2004. A highly conserved glycine within linker I and the extreme C-terminus of G protein a subunits interact cooperatively in switching GPCR-to-effector specificity. J. Pharmacol Exp Ther. 313(1):78-87.

A. Heydorn, B.P. Søndergaard, B. Ersbøll, B. Holst, F.C. Nielsen, C. R. Haft, J.L. Whistler, T.W. Schwartz. 2004. A library of 7TM receptor c-terminal tails: Interactions with the proposed post-endocytic sorting proteins EBP50, NSF, SNX1 and GASP. J. Biological Chemistry. 279(52): 54291-303.

M. Waldhoer, S.E. Bartlett and J.L. Whistler. 2004. Opioid Receptors.Annual Reviews in Biochemistry, 73:953-990.

Waldhoer, M., Casarosa, P., Rosenkilde, M.M., Smit, M.J., Leurs, R., Whistler, J.L., Schwartz, T.W. 2003.The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biological Chemistry. 278(21):19473-82.

Whistler, J.L., Gerber, B.O., Meng, E.C., Baranski, T.J., von Zastrow, M., Bourne, H.R. 2002. Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic, 3(12):866-77.

Whistler, J.L., Enquist, J., Marley, A., Fong, J., Gladher, F., Tsuruda, P., Murray, S., and von Zastrow, M. 2002. Modulation of postendocytic sorting of G protein-coupled receptors. Science, 297(5581):615-20.

Alvarez, V.A., Arttamangkul, S., Dang, V., Salem, A., Whistler, J.L., von Zastrow, M., Grandy, D. and Williams, J.T. 2002. Mu-Opioid receptors: activation of potassium conductance, desensitization and internalization. Journal of Neuroscience 22(13):5769-5776.

Bartlett, S.E. and Whistler, J.L. 2002. The near death experience of delta opioid receptors leads to new drug targets. Molecular Interventions, 2(3):12-14

He, L., Fong, J., von Zastrow, M., and Whistler, J.L. 2002. Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization. Cell, 108(2):271-282.

Finn, A.K. and Whistler, J.L. 2001. Endocytosis of the Mu Opioid Receptor Reduces Tolerance and a Cellular Hallmark of Opiate Withdrawal. Neuron, 32(5):829-839. Also featured with the cover and a minireview.

Whistler, J.L., Tsao, P., and von Zastrow, M. 2001. A phosphorylation-regulated brake mechanism controls the initial endocytosis of opioid receptors but is not required for post-endocytic sorting to lysosomes. J Biological Chemistry, 276(36):34331-34338.

Whistler, J.L. and von Zastrow, M. 2000. Regulated Internalization of Opioid Receptors: Implications for the Biology of Opiate Tolerance. The Neuroscientist.

Whistler, J.L., Beattie, E., and von Zastrow, M. 2000. Tales from the Crypt: Evidence for Heptahelical Receptor Signaling in the Endocytic Pathway. Science, Signal Transduction Knowledge Environment, 29 August.

Whistler, J.L., Chuang, H-h., Chu, P., Jan, L.Y. and von Zastrow, M. 1999. Functional Dissociation of Mu Opioid Receptor Signaling and Endocytosis: Implications for the Biology of Opiate Tolerance and Addiction. Neuron, 23(4):737-746, also see preview page 629-630.

Whistler, J.L. and von Zastrow, M. 1999. Dissociation of Functional Roles of Dynamin in Receptor-mediated Endocytosis and Mitogenic Signal Transduction. J Biological Chemistry, 274(35):24575-24578.

Whistler, J.L. and von Zastrow, M. 1998. Morphine-activated Opioid Receptors Elude Desensitization by Beta-arrestin. Proceedings of the National Academy of Sciences, 95(17):9914-9919.