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Selected References for Jennifer Whistler

J.A. Kim, S. Bartlett, L. He, C.K. Nielsen, A.M. Chang, V. Kharazia, M. Waldhoer, C.J. Ou, S. Taylor, M. Ferwerda, D. Cado, J.L. Whistler. 2008. Morphine-Induced Receptor Endocytosis in a Novel Knockin Mouse Reduces Tolerance and Dependence. Current Biology. 18(2):129-135.  

L. Martini, J.L. Whistler. 2007. The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence. Curr. Opin. Neurobiol. 17(5):556-64.

D. Thompson, M. Pusch, J.L. Whistler. 2007. Changes in G protein coupled receptor sorting protein affinity regulate post-endocytic targeting of G protein coupled receptors. J Biological Chemistry 282(40):29178-29185.

Y.F. Xia, L. He, J.L. Whistler, G.O. Hjelmstad. 2007. Acute Amphetamine Axposure Selectively Desensitizes kappa Opioid Receptors in the Nucleus Accumbens. Neuropsychopharmacology.

A.W. Lasek, P.H. Janak, L. He, J.L. Whistler, U Heberlein. 2007. Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. Genes Brain and Behavior. 6(8):728-735.

L. He, J.L. Whistler, 2007. The Biochemical Analysis of Methadone Modulation on Morphine-Induced Tolerance and Dependence in the Rat Brain. Pharmacology 79(4):193-202.

A. Tappe-Theodor, N. Agarwal, I. Katona, T. Rubino, L. Martini, J. Swiercz, K. Mackie, H. Monyer, D. Parolaro, J. Whistler, T. Kuner, R. Kuner. 2007. A Molecular Basis of Analgesic Tolerance to Cannabinoids. Journal of Neuroscience 27(15):4165-4177.

L. Martini, M. Waldhoer, M. Pusch, V. Kharazia, J. Fong, J.H. Lee, C. Freissmuth, J.L. Whistler. 2007. Ligand-induced down-regulation of cannabinoid 1 receptor is mediated by G-protein-coupled receptor-associated sorting protein GASP1. FASEB J 21(3):802-11.

J. Enquist,C. Skroder, J.L. Whistler, L.M. Leeh-Lundberg. 2006. Kinins promote B2 receptor endocytosis and delay constitutive B1 receptor receptor endocytosis. Molecular Pharmacology 71(2):494-507.

S. Bartlett*, J. Enquist*, F.W. Hopf*, J. Lee, F. Gladher, V. Kharazia, W. Maillaird, M. Waldhoer, R Armstrong, A. Bonci and J.L. Whistler. 2005. Dopamine responsiveness is regulated by targeted sorting of D2 receptors. Proceedings National Academy of Sciences 102(32):11520–11526.

L. He, and J.L. Whistler. 2005. An opiate cocktail that prevents morphine tolerance and dependence. Current Biology 15(11):1028-33.

M. Waldhoer, J. Fong, E. M. Lunzer, R. Jones, S. Sharma, E. Kostenis, P. Portoghese, J.L. Whistler. 2005. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proceedings National Academy of Sciences 102(25):9050-9055. Also featured on the cover.

S.E. Bartlett and J.L.Whistler 2005. The G protein coupled receptor handbook: Receptor Oligomerization and Trafficking. Humana Press, 309-322.

E. Kostenis, L. Martini, J. Ellis, M. Rosenkilde, M. Waldhoer, P. K. Norregaard, A. Heydorn, J.L. Whistler, G. Milligan. 2004. A highly conserved glycine within linker I and the extreme C-terminus of G protein a subunits interact cooperatively in switching GPCR-to-effector specificity. J. Pharmacol Exp Ther. 313(1):78-87.

A. Heydorn, B.P. Søndergaard, B. Ersbøll, B. Holst, F.C. Nielsen, C. R. Haft, J.L. Whistler, T.W. Schwartz. 2004. A library of 7TM receptor c-terminal tails: Interactions with the proposed post-endocytic sorting proteins EBP50, NSF, SNX1 and GASP. J. Biological Chemistry. 279(52): 54291-303.

M. Waldhoer, S.E. Bartlett and J.L. Whistler. 2004. Opioid Receptors.Annual Reviews in Biochemistry, 73:953-990.

Waldhoer, M., Casarosa, P., Rosenkilde, M.M., Smit, M.J., Leurs, R., Whistler, J.L., Schwartz, T.W. 2003.The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. J Biological Chemistry. 278(21):19473-82.

Whistler, J.L., Gerber, B.O., Meng, E.C., Baranski, T.J., von Zastrow, M., Bourne, H.R. 2002. Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor. Traffic, 3(12):866-77.

Whistler, J.L., Enquist, J., Marley, A., Fong, J., Gladher, F., Tsuruda, P., Murray, S., and von Zastrow, M. 2002. Modulation of postendocytic sorting of G protein-coupled receptors. Science, 297(5581):615-20.

Alvarez, V.A., Arttamangkul, S., Dang, V., Salem, A., Whistler, J.L., von Zastrow, M., Grandy, D. and Williams, J.T. 2002. Mu-Opioid receptors: activation of potassium conductance, desensitization and internalization. Journal of Neuroscience 22(13):5769-5776.

Bartlett, S.E. and Whistler, J.L. 2002. The near death experience of delta opioid receptors leads to new drug targets. Molecular Interventions, 2(3):12-14

He, L., Fong, J., von Zastrow, M., and Whistler, J.L. 2002. Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization. Cell, 108(2):271-282.

Finn, A.K. and Whistler, J.L. 2001. Endocytosis of the Mu Opioid Receptor Reduces Tolerance and a Cellular Hallmark of Opiate Withdrawal. Neuron, 32(5):829-839. Also featured with the cover and a minireview.

Whistler, J.L., Tsao, P., and von Zastrow, M. 2001. A phosphorylation-regulated brake mechanism controls the initial endocytosis of opioid receptors but is not required for post-endocytic sorting to lysosomes. J Biological Chemistry, 276(36):34331-34338.

Whistler, J.L. and von Zastrow, M. 2000. Regulated Internalization of Opioid Receptors: Implications for the Biology of Opiate Tolerance. The Neuroscientist.

Whistler, J.L., Beattie, E., and von Zastrow, M. 2000. Tales from the Crypt: Evidence for Heptahelical Receptor Signaling in the Endocytic Pathway. Science, Signal Transduction Knowledge Environment, 29 August.

Whistler, J.L., Chuang, H-h., Chu, P., Jan, L.Y. and von Zastrow, M. 1999. Functional Dissociation of Mu Opioid Receptor Signaling and Endocytosis: Implications for the Biology of Opiate Tolerance and Addiction. Neuron, 23(4):737-746, also see preview page 629-630.

Whistler, J.L. and von Zastrow, M. 1999. Dissociation of Functional Roles of Dynamin in Receptor-mediated Endocytosis and Mitogenic Signal Transduction. J Biological Chemistry, 274(35):24575-24578.

Whistler, J.L. and von Zastrow, M. 1998. Morphine-activated Opioid Receptors Elude Desensitization by Beta-arrestin. Proceedings of the National Academy of Sciences, 95(17):9914-9919.