Home Translational Research Preclinical Development People Joan Holgate
Joan Holgate PDF Print E-mail
joan.jpgJunior Specialist

Contact Information:
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Job Description: Assist in the management of the laboratory and research projects. Perform behavioral, biochemical and histological assays.
Research Interests: Understanding how neurological signaling pathways and receptors, such as the m opioid, D2-like dopamine, and serotonin(5HT)-1A receptor pathways, modulate pain, anxiety, depression and substance abuse.

Publications:

van den Buuse M, Martin S, Holgate J, Matthaei K, Hendry I. Mice deficient in the alpha subunit of G (z) show changes in pre-pulse inhibition, anxiety and response to 5-HT (1A) receptor stimulation, which are strongly dependent on the genetic background. Psychopharmacology (Berl). 2007 Dec;195(2):273-83. Epub 2007 Aug 9.
PMID: 17684732 [Pubmed - in process]

Steensland, P., Simms, J.A., Holgate, J., Richards, J.K., and Bartlett, S.E. (2007) Varenicline, an a4b2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. PNAS published July 11, 2007, 10.1073/pnas.0705368104.

Leck KJ, Blaha CD, Matthaei KI, Forster GL, Holgate J, Hendry IA. Gz proteins are functionally coupled to dopamine D2-like receptors in vivo. Neuropharmacology. 2006 Sep;51(3):597-605. Epub 2006 Jun 30.
PMID: 16814816 [PubMed - indexed for MEDLINE]

Holgate, J. Investigation of the neonatal mortality phenotype in Gaz knockout mice: A role for Gz in the oxytocin pathway. Thesis for Grad Dip Sc (Neuroscience), 2005 Oct, The Australian National University.

Leck KJ, Bartlett SE, Smith MT, Megirian D, Holgate J, Powell KL, Matthaei KI, Hendry IA. Deletion of guanine nucleotide binding protein alpha z subunit in mice induces a gene dose dependent tolerance to morphine. Neuropharmacology. 2004 May;46(6):836-46.
PMID: 15033343 [PubMed - indexed for MEDLINE]

Contributions to published articles:

Oleskevich S, Leck KJ, Matthaei K, Hendry IA. Enhanced serotonin response in the hippocampus of Galphaz protein knock-out mice. Neuroreport. 2005 Jun 21;16(9):921-5.
PMID: 15931062 [PubMed - indexed for MEDLINE]


Previous Employment: The John Curtin School of Medical Research, Australian National University