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Translational Research Preclinical Development People Jeffrey Simms
Translational Research Preclinical Development People Jeffrey Simms
| Jeffrey Simms |
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 Staff Research Associate IIIContact Information: Email: This e-mail address is being protected from spambots, you need JavaScript enabled to view it Job Description: Manage preclinical drug screening and model development and run daily behavioral experiments.
Research Interests: A shared area of interest within our group is the search for novel medications for the treatment of alcohol dependence. It's exciting to be part of the process of translating basic research discoveries into drugs that could potentially help those struggling with alcoholism. At the present time, my particular area of interest is the CRF system and its involvement in ethanol-mediated behaviors. Using microdialysis and local infusions we hope to gain a better understanding of the effects of CRF on the mesocorticolimbic DA pathway and, in particular, its role in ethanol consumption and reinstatement.
Publications: Simms, J.A., Steensland, P., Medina, B., Abernathy, K., Chandler, L.J., Wise, R.A., and Bartlett, S.E. (2008) Intermittent-Access to 20% Ethanol induces high ethanol consumption in Long-Evans and Wistar rats. Alcoholism: Clinical and Experimental Research, 32:1-8. Richards, J.K., Simms, J.A.and Bartlett, S.E. Conditioned cues and yohimbine induce reinstatement of beer and near beer seeking in Long-Evans rats. Addiction Biology (in press). Steensland, P., Simms, J.A., Holgate, J., Richards, J.K., and Bartlett, S.E. (2007) Varenicline, an a4b2 nicotinic acetylcholine receptor partial agonist, selectively decreases ethanol consumption and seeking. PNAS published July 11, 2007, 10.1073/pnas.0705368104. Dayas CV, Liu X, Simms JA, Weiss F. Distinct Patterns of Neural Activation Associated with Ethanol Seeking: Effects of Naltrexone. Biol Psychiatry. 2006 Nov 9; [Epub ahead of print]. PMID: 17098214 [PubMed - as supplied by publisher] Contributions to published articles: Dayas CV, Martin-Fardon R, Thorsell A, Weiss F. Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats. Alcohol Alcohol. 2004 May-Jun;39(3):190-6. PMID: 15082455 [PubMed - indexed for MEDLINE] Ciccocioppo R, Martin-Fardon R, Weiss F. Stimuli associated with a single cocaine experience elicit long-lasting cocaine-seeking. Nat Neurosci. 2004 May;7(5):495-6. Epub 2004 Mar 28. PMID: 15048121 [PubMed - indexed for MEDLINE] Previous Employment: The Scripps Research Institute |