Best Natural PDE5 Inhibitors

Best Natural PDE5 Inhibitors

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Over 18 million men in the U.S. have erectile difficulties. A lack of minerals, vitamins, and healthy foods can massively disturb testosterone levels (1).

For the last two decades, synthetic and natural pde5 inhibitors have been the go-to choice for managing this problem (2).

If you experience erectile dysfunction, you should address the problem at the first sign of trouble. Herbs that inhibit PDE5 naturally can help you achieve that.

Here, we’ve decided to compile all the essential info on these inhibitors. Including what they are, what kind of effect they have, and how they can help you solve an erectile problem.


What Are Natural PDE5 Inhibitors?

Remedies like Horny goat weed and Artichoke inhibit PDE5 naturally. These herbs are what we call natural PDE5 inhibitors. They are a cost-effective method for managing mild erectile dysfunction. As well as other less severe penile difficulties (3).

They inhibit the body the same way as synthetic PDE5 inhibitors, like Viagra or Cialis. The herbs first enter the system. Then, they travel to the cavernous corpus tissue in the penis (a sponge-like section where the blood stacks during an erection).

The PDE5 inhibitors work naturally for impotence. To put it bluntly, herbs can help the penis get an erection.

But, compared to synthetic PDE5 inhibitors, they don’t use blunt force. They are easy on the system and beneficial for the body if you use them correctly. They can’t cause serious side effects, either. As a result, researchers consider them relatively safe for consumption (4).

What Makes PDE5 Inhibitors Important?

There is one essential substance that plays a vital role in maintaining an erection. We call it the cGMP or guanosine monophosphate.

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This substance forces the red blood cells in the system to give up nitric oxide. But, there is also something else in the body that keeps the cGMP under control – PDE5 (5).

When PDE5 is overly active, it will affect the levels of cGMP in your system. As a result, people will find it difficult or almost impossible to get an erection.

When you take synthetic PDE5 inhibitors, the chemical compounds in the drugs will block the PDE5. That’s why some people can experience side effects. Natural inhibitors are entirely different. They accompany the effects to the system without blocking PDE5.

5 Herbs That Inhibit PDE5 Naturally

Over the years, people have studied a lot of plants. But, for the male population, anything that could help with penile difficulties was always welcome. The main remedies were natural PDE5 inhibitors.

People praised them for their aphrodisiac properties and relied on them to get a better erection. Now, researchers have studied their effects. Some of these herbs that inhibit PDE5 naturally are now a common addition to supplements and pills (6).

We have decided to list the more popular natural inhibitors that can come in handy.

1. Cinnamon

Cinnamon is a potent PDE5 inhibitor. It has powerful aphrodisiac effects that can be useful for managing erectile problems. In animal studies, the rats that consumed cinnamon extracts regularly increased their sexual function by 43%. They also reduced the collagen in the penile tissue (7).

2. Panax Ginseng

If you want Viagra-like effects but without the side effects, you should try Panax Ginseng. This is the “natural” Viagra. Anything from 600 to 1,000 mg, three times a day, can be an effective solution for managing erectile difficulties. It can improve the problem on a cellular level and reduce erectile dysfunction (8).

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3.  Horny Goat Weed

This is a well-known herb for erectile difficulties found in supplements like Performer 8 or VigRX Plus. People use it for its potent therapeutic properties and inhibitory effects (9).

When an individual consumes the herb, the icariin will inhibit the PDE5 function that’s blocking the arteries. As a result, it can allow blood to reach the cylinders and arteries in the penis and dilate the organ. This is how the natural inhibitor helps the body achieve an erection (10).

Compared to typical synthetic inhibitors and medications, this herb doesn’t result in a series of health issues. Instead, it boosts the libido and ensures better testosterone levels.

4. Forskolin

If you’ve heard of the coleus plant, then you are most likely familiar with its extract – forskolin. People mostly use it to burn fat, but it has another role. It can inhibit PDE5 and estrogen synthase, the enzyme responsible for biosynthesis (11).

Its fat reduction properties are working against estrogen synthase. And since this is where the body stores the fat, the more estrogen synthase, the easier it is to control the testosterone levels.

Simply put, it can help shed some pounds, inhibit PDE5, and increase testosterone. This herb is a relatively new addition to the market. Therefore, more research is necessary to know the full extent of its properties.

5. Artichoke

An extract from the artichoke leaves can be a potent PDE5 inhibitor (12). It contains Luteolin, which is popular for its anti-inflammatory compounds. When a person uses the extract, the Luteolin will immediately scavenge the system for free radicals. Then it will try to suppress their synthesis.

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Another reason for its potent effect lies in flavonoids (13). Artichoke is rich in flavonoids and other nutrients that benefit the body. All the compounds will inhibit estrogen synthase and convert the testosterone into estrogen.


Some natural PDE5 inhibitors have plenty of aphrodisiac effects and therapeutic properties. But, people mainly use them for erectile difficulties. If you want inhibitory effects, it can be helpful to try some herbs to treat the problem. The options we listed above can come in handy.