Robert O. Messing, MD
Vice President, Internal
Affairs
Professor of Neurology, UCSF
Endowed Chair in Neurology in Honor of the Gallo
Family, UCSF
Director, Alcohol Center for
Translational Genetics
Member, UCSF Graduate Program in
Neuroscience
Member, UCSF Program in Biological Sciences
Member, Wheeler Center for the
Neurobiology of Addiction
Member, UCSF Graduate Group in Oral and Craniofacial
Sciences
Member, UCSF Institute of Molecular Medicine
Phone: (510) 985-3950
Carol Webb (Executive Assistant): (510) 985-3853, cwebb@gallo.ucsf.edu
Email: romes@gallo.ucsf.edu
Research
My laboratory studies molecular mechanisms that
underlie addiction and co-morbid conditions such as
anxiety and pain. We have focused on signal
transduction pathways that involve the protein kinase C
(PKC) family of serine-threonine kinases. In cultured
neuronal cell lines, ethanol alters the localization
and increases the abundance of two PKC isozymes,
PKCdelta and PKCepsilon. In addition, comparative
transcriptome analysis of mice that show high versus
low ethanol consumption has shown that PKCepsilon and
PKCzeta are highly expressed in the brains of mice
that consume large amounts of ethanol. Therefore, my
laboratory is examining PKCdelta, PKCepsilon, and
PKCzeta to understand the role of these kinases and
their signaling pathways in behavior and to identify
targets for development of new therapeutic agents to
treat addiction. The techniques we use include gene
targeting, RNA interference, and chemical genetics with
mutant kinases that utilize ATP analogs.
more ...
Lab Members
Jahan Dadgar, Staff Research Associate, jdadgar@gallo.ucsf.edu
Frederic
Woody Hopf, Associate Investigator, woody@gallo.ucsf.edu
David Kapfhamer, Assist Research Scientist, dkapfhamer@gallo.ucsf.edu
Anna Lee, Postdoctoral Fellow, amlee@gallo.ucsf.edu
Rajani Maiya, Assist Research Scientist, rmaiya@gallo.ucsf.edu
Thomas McMahon, Senior Staff Research Associate, tomm@gallo.ucsf.edu
Taban Seif, Postdoctoral Fellow, tseif@gallo.ucsf.edu
Jeffrey Simms, Staff Research Associate, jsimms@gallo.ucsf.edu
Subhashini Srinivasan, Postdoctoral Fellow, ssrinivasan@gallo.ucsf.edu
Jacklyn Stecher, Supervisor, Lab Assistant, jackiec@gallo.ucsf.edu
Dan Wang, Specialist, danw@gallo.ucsf.edu
Daifei Wu, Postdoctoral Fellow, dwu@gallo.ucsf.edu
Yun Zhang, Staff Research Associate, yzhang@gallo.ucsf.edu
Publications
Robert
O. Messing's selected publications
Robert O. Messing's publications
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