Ernest Gallo Clinic and Research Center   At the University of California, San Francisco
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GALLO INVESTIGATORS
Steven Batki
Kevin Bender
Robert Edwards
Howard Fields
Patricia Janak
Andrew Kayser
Robert Messing
Dorit Ron
Jennifer Whistler
Linda Wilbrecht
Joshua Woolley
Gallo Investigators
Robert Messing

Robert O. Messing, MD

Vice Provost for Biomedical Sciences
Henry M. Burlage Centennial Professor of Pharmacy
University of Texas at Austin

In 2012 Dr. Messing's lab moved to The University of Texas at Austin. Dr. Messing is now an affiliated investigator at the Gallo Center.

Research

My laboratory studies molecular mechanisms that underlie addiction and co-morbid conditions such as anxiety and pain. We have focused on signal transduction pathways that involve the protein kinase C (PKC) family of serine-threonine kinases. In cultured neuronal cell lines, ethanol alters the localization and increases the abundance of two PKC isozymes, PKCdelta and PKCepsilon. In addition, comparative transcriptome analysis of mice that show high versus low ethanol consumption has shown that PKCepsilon and PKCzeta are highly expressed in the brains of mice that consume large amounts of ethanol. Therefore, my laboratory is examining PKCdelta, PKCepsilon, and PKCzeta to understand the role of these kinases and their signaling pathways in behavior and to identify targets for development of new therapeutic agents to treat addiction. The techniques we use include gene targeting, RNA interference, and chemical genetics with mutant kinases that utilize ATP analogs.

CONTACT US
5858 Horton Street, Suite 200
Emeryville, CA 94608
Phone: (510) 985-3109

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